Molecular Biology: News, Information and Journals

A New Approach for the Joint Analysis of Multiple Chip-Seq Libraries with Application to Histone Modification

Posted from Statistical Applications in... 99 days ago
Molecular Biology : Molecular Biology Information

Most approaches for analyzing ChIP-Seq data are focused on inferring exact protein binding sites from a single library. However, frequently multiple ChIP-Seq libraries derived from differing cell lines or tissue types from the same individual may be available. In such a situation, a separate analysis for each tissue or cell line may be inefficient. Here, we describe a novel method to analyze such data that intelligently uses the joint information from multiple related ChIP-Seq libraries. We present our method as a two-stage procedure. First, separate single cell line analysis is performed for ... (original story)