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Multiple Roles of Heparin in the Aggregation of p25alpha

Posted from Journal of Molecular Biology 99 days ago
Molecular Biology : Molecular Biology Journals

Publication Date: 2012 Feb 3 PMID: 22326478Authors: Nielsen, S. B. - Yde, P. - Giehm, L. - Sundbye, S. - Matthiesen, J. - Jensen, M. H. - Jensen, P. H. - Otzen, D. E.Journal: J Mol BiolThe 219-residue protein p25alpha stimulates the fibrillation of alpha-synuclein (alphaSN) in vitro and colocalizes with it in several alpha-synucleinopathies. Although p25alpha does not fibrillate by itself under native conditions in vitro, alphaSN-free p25alpha aggregates have also been observed in vivo in, for example, multiple system atrophy. To investigate which environmental conditions might trigger this ag... (original story)