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The Effect of Abeta on IAPP Aggregation in the Presence of an Isolated beta-Cell Membrane.

Posted from Journal of Molecular Biology 99 days ago
Molecular Biology : Molecular Biology Journals

Publication Date: 2012 Feb 1 PMID: 22321797Authors: Seeliger, J. - Weise, K. - Opitz, N. - Winter, R.Journal: J Mol BiolFibrillar aggregates of the islet amyloid polypeptide (IAPP) and amyloid-beta (Abeta) are known to deposit at pancreatic beta-cells and neuronal cells and are associated with the cell degenerative diseases type-2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), respectively. Since IAPP is secreted by beta-cells and a membrane-damaging effect of IAPP has been discussed as a reason for beta-cell dysfunction and the development of T2DM, studies of the interaction of IAPP w... (original story)