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Recent Molecular Biology Journals

High levels of wild-type BRCA2 suppress homologous recombination.

Posted from Journal of Molecular Biology 3 days ago
Molecular Biology : Molecular Biology Journals

Publication Date: 2012 May 9 PMID: 22579622Authors: Magwood, A. C. - Mundia, M. M. - Baker, M. D.Journal: J Mol BiolEndogenous levels of the breast cancer susceptibility 2 (BRCA2) protein promote homologous recombination by regulating the essential strand exchange protein RAD51. To examine BRCA2 fun... (original story)

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Conformation of the troponin core complex in the thin filaments of skeletal muscle during relaxation and active contraction.

Posted from Journal of Molecular Biology 3 days ago
Molecular Biology : Molecular Biology Journals

Publication Date: 2012 May 9 PMID: 22579625Authors: Knowles, A. C. - Irving, M. - Sun, Y. B.Journal: J Mol BiolContraction of skeletal and cardiac muscles is regulated by Ca(2+) ions binding to troponin in the actin-containing thin filaments, leading to an azimuthal movement of tropomyosin around th... (original story)

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Structural Analysis of the Substrate Recognition Mechanism in O-phosphoserine Sulfhydrylase from the Hyperthermophilic Archaeon Aeropyrum pernix K1.

Posted from Journal of Molecular Biology 3 days ago
Molecular Biology : Molecular Biology Journals

Publication Date: 2012 May 10 PMID: 22580223Authors: Nakamura, T. - Kawai, Y. - Kunimoto, K. - Iwasaki, Y. - Nishii, K. - Kataoka, M. - Ishikawa, K.Journal: J Mol Bioll-Cysteine is synthesized from O-acetyl-l-serine (OAS) and sulfide by O-acetylserine sulfhydrylase (OASS; EC 2.5.1.47) in plants and ... (original story)

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Lateral Clustering of TLR3:dsRNA Signaling Units Revealed by TLR3ecd:3Fabs Quaternary Structure.

Posted from Journal of Molecular Biology 3 days ago
Molecular Biology : Molecular Biology Journals

Publication Date: 2012 May 9 PMID: 22579623Authors: Luo, J. - Obmolova, G. - Malia, T. J. - Wu, S. J. - Duffy, K. - Marion, J. D. - Bell, J. K. - Ge, P. - Zhou, Z. H. - Teplyakov, A. - Zhao, Y. - Lamb, R. - Jordan, J. - San Mateo, L. - Sweet, R. W. - Gilliland, G. L.Journal: J Mol BiolToll-like rece... (original story)

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Molecular effects of Familial Hypertrophic Cardiomyopathy-related mutations in the TNT1 domain of cTnT.

Posted from Journal of Molecular Biology 3 days ago
Molecular Biology : Molecular Biology Journals

Publication Date: 2012 May 9 PMID: 22579624Authors: Manning, E. P. - Tardiff, J. C. - Schwartz, S. D.Journal: J Mol BiolFamilial hypertrophic cardiomyopathy (FHC) is one of the most common genetic causes of heart disease. Approximately 15% of FHC-related mutations are found in cardiac troponin T (cT... (original story)

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Auto-inhibition of ETV6 (TEL) DNA-binding: appended helices sterically block the ETS domain.

Posted from Journal of Molecular Biology 3 days ago
Molecular Biology : Molecular Biology Journals

Publication Date: 2012 May 11 PMID: 22584210Authors: Coyne, H. J. 3rd - De, S. - Okon, M. - Green, S. M. - Bhachech, N. - Graves, B. J. - McIntosh, L. P.Journal: J Mol BiolETV6 (or TEL), a transcriptional repressor belonging to the ETS family, is frequently involved in chromosomal translocations lin... (original story)

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Crystal Structure of Human Methyl-Binding Domain IV Glycosylase Bound to Abasic DNA.

Posted from Journal of Molecular Biology 12 days ago
Molecular Biology : Molecular Biology Journals

Publication Date: 2012 May 2 PMID: 22560993Authors: Manvilla, B. A. - Maiti, A. - Begley, M. C. - Toth, E. A. - Drohat, A. C.Journal: J Mol BiolThe mammalian repair protein MBD4 (methyl-CpG-binding domain IV) excises thymine from mutagenic G.T mispairs generated by deamination of 5-methylcytosine (m... (original story)

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Histone H4 K16Q mutation, an acetylation mimic, causes structural disorder of its N-terminal basic patch in the nucleosome.

Posted from Journal of Molecular Biology 12 days ago
Molecular Biology : Molecular Biology Journals

Publication Date: 2012 May 7 PMID: 22575889Authors: Zhou, B. R. - Feng, H. - Ghirlando, R. - Kato, H. - Gruschus, J. - Bai, Y.Journal: J Mol BiolHistone tails and their post-translational modifications (PTM) play important roles in regulating the structure and dynamics of chromatin. For histone H4, ... (original story)

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Effects of mutation, truncation and temperature on the folding kinetics of a WW domain.

Posted from Journal of Molecular Biology 12 days ago
Molecular Biology : Molecular Biology Journals

Publication Date: 2012 May 2 PMID: 22560992Authors: Maisuradze, G. G. - Zhou, R. - Liwo, A. - Xiao, Y. - Scheraga, H. A.Journal: J Mol BiolThe purpose of this work is to show how mutation, truncation and change of temperature can influence the folding kinetics of a protein. This is accomplished by p... (original story)

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NMR and crystalstructures of the Pyrococcus horikoshii RadA intein guide a strategy for engineering a highly efficient and promiscuous intein.

Posted from Journal of Molecular Biology 12 days ago
Molecular Biology : Molecular Biology Journals

Publication Date: 2012 May 2 PMID: 22560994Authors: Oeemig, J. S. - Zhou, D. - Kajander, T. - Wlodawer, A. - Iwai, H.Journal: J Mol BiolIn protein splicing, an intervening protein sequence (intein) in the host protein excises itself out and ligates two split host protein sequences (exteins) to produ... (original story)